Striking While the Iron Was Hot, Aastrom Biosciences (ASTM)

January 25th, 2010 Henry McCusker No comments

The public offering/ financing further strengthened its’ balance sheet and to complete ongoing Phase II clinical trials:

  • Receiving approximately $12.4 M from the sale of units including the over-allotment,
  • The 52,077,100 units consisted of 52,077,100 shares of common stock, Class A Warrants to purchase an aggregate of 39,057,825 shares of common stock and Class B Warrants to purchase an aggregate of 26,038,550 shares of common stock,
  • Each  Class A Warrant entitles the holder to acquire 1 share of common stock upon payment of $0.3718 per share, exercisable for a 5 year period commencing on a date 6 months after the closing date and each whole Class B Warrant entitles the holder to acquire 1 share of  common stock upon payment of $0.26 per share, exercisable for a 6 month period,
  • The public offering format was better then a PIPE or an RDO as retail investors could  participate,
  • The stock tumbled to $0.23 after ASTM priced the offering  at $0.26 a share,
  • The GOOD news … the “pre-baked” offering was over-subscribed … as a few investors could not get in,
  • The offering was done at $0.26 while the stock was trading lower, now at $0.236, up $0.007 and continuing to … edge-up,
  • Investors (and ME) should have realized something was in the air when ASTM amended (12/09) its Restated Articles of Incorporation that increased the authorized shares of common stock from 250 M to 500 M,
  • The fully diluted value is heavy with approximately 230 M (+) of outstanding shares plus warrants plus the incentive options,
  • But, the reverse is … still … DUE … to eliminate by 3/31/10 the NASDAQ listing issue,
  • So, the question is creating a share price balancing act of appreciation to the future,
  • News is the … only factor as interim clinical data from its cardiac and limb ischemia  trials are due,
  • The pure risk benefit … made sense … unfortunately price depreciation was inevitable … as in biotech, dilution is a constant,
  • The REAL choice was the value of money, now or later,
  • However, the proxy vote for the reverse split defined a range of 5 to 8 for 1,
  • We can all multiply the current price against/with the current price but no one wants a post-reverse sell-off,
  • Responding to our 1/15/10 post: the new CEO, Tim Mayleben deserves credit for a big and bold move … with this market slipping as it has: he raised $$, added a few institutions/hedge funds but, the piper (reverse) still has to be paid,
  • Ranked a … BUY … as still below the offering pricing and news is due.

JPMorgan Healthcare Conference 2010: Trends and Company Updates

January 19th, 2010 rraynovitch No comments

Over 6000 people piled into the Westin St. Francis Hotel in San Francisco for the 28th Annual Conference. Investors, Company presenters and entrepreneurs were emboldened by  good biotech sector returns in 2009 of 18-28% with many stocks reaching new highs. Seasonality has been a factor with the so-called “January effect” where  small cap stocks tend to spike up due to a number of factors but this Conference has been paramount. For example the IBB ETF is up about 6% from November levels.

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Access Pharma’s Drug Delivery Technology is a Stealth Asset

January 19th, 2010 Mike Havrilla No comments

Access Pharma (OTC: ACCP.OB) provided an update today on the status of its cobalamin-based oral drug delivery product development programs. The BioMedReports.com research downloads section and the ProActive News Room website for Access both contain the most recent research reports and presentation for the Company, following its presentation last week at the OneMed Forum in San Francisco, which was held in conjunction with the JP Morgan Healthcare Conference.

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Healthcare Conference Update: A New Strategy for IMUC

January 17th, 2010 Mike Havrilla No comments

I had the opportunity last week to discuss the updated strategy and expected milestones for ImmunoCellular Therapeutics (OTC: IMUC.OB) in 2010 and beyond with CEO, Manish Singh, following the conclusion of the OneMed, JP Morgan, and other healthcare conferences in San Francisco. IMUC is an emerging cancer immunotherapy company that is developing therapeutic and diagnostic product candidates taking aim at the root cause of the disease, cancer stem cells, based on two technology platforms that include active (therapeutic cancer vaccines) and passive (monoclonal antibodies) approaches.

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Healthcare Conference Updates: AUXL, CTIC, CYTX, KERX

January 15th, 2010 Mike Havrilla No comments

Below are some updates and developments from the past week, which I spent in San Francisco for the OneMed, JP Morgan, and other healthcare conferences.

I had the opportunity to meet with the CEO (Ron Bentsur) and CFO (James Oliviero) of Keryx Biopharma (NASDAQ: KERX) on Wednesday and was impressed with the Company’s focused strategy and upcoming milestones for 2010 and beyond. As outlined in my overview article last week, I have purchased shares of KERX over the past week on weakness at a slightly higher price range ($2.70-2.75) than I originally projected.

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A Very Big Bet, Aastrom Biosciences (ASTM)

January 15th, 2010 Henry McCusker No comments

ASTM announced, 1/14/10 that it intends to offer to sell, subject to market and other conditions, units consisting of shares of its common stock, Class A warrants and Class B warrants, in an underwritten public offering.

  • ASTM will grant the underwriter an over-allotment option to purchase additional shares of common stock and/or warrants in an amount up to 15% of the number of shares of common stock and warrants underlying the units sold pursuant to the offering. These additional shares of common stock and/or warrants would be exercisable at any time up to 30 days from the pricing of the offering (Oppenheimer & Co is acting as the sole underwriter for the offering).

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Up, Up and Away: BioTime (AMEX:BTIM)

January 14th, 2010 Henry McCusker No comments

BioTime, Inc (Amex: BTIM) develops blood plasma volume expanders and blood replacement solutions for hypothermic (low temperature) surgery, and organ preservation solutions and technology for use in surgery, emergency trauma treatment, and other applications.

Focus: BioTime develops and markets research products in the field of stem cells and regenerative medicine through its wholly owned subsidiary Embryome Sciences.

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Pluristem Therapeutics (NASDAQ: PSTI)

January 13th, 2010 Henry McCusker No comments

Pluristem Therapeutics (NASDAQ: PSTI) is engaged in the production, research and development of placental-derived adherent stromal cells (ASCs). PSTI commercializes  non-personalized (allogeneic) cell therapy products for the treatment of various severe degenerative, ischemic and autoimmune disorders.

Focus: PSTI develops a pipeline of products that are derived from the human placenta, a non-controversial, non-embryonic, adult stem cell source. These placental adherent stromal cells (ASCs) are expanded in proprietary PluriXTM  3 dimensional bio-reactors; which imitates the natural micro-structure of bone marrow and does not require supplemental growth factors or other exogenous materials.

  • Their principal product in development is PLX-PAD for people suffering from peripheral artery disease and also include PLX-IBD, which targets inflammatory bowel disease; PLX-MS, targeting multiple sclerosis; PLX-BMT that targets the global shortfall of matched tissue for bone marrow transplantation (BMT) by enhancing the engraftment of hematopoietic stem cells (HSCs) contained in umbilical cord blood and PLX-STROKE, targeting ischemic stroke.

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Cash, Partners, Advanced Trials; Osiris Therapeutics

January 12th, 2010 Henry McCusker No comments

Osiris Therapeutics (NASDAQ: OSIR) has focused on the advancement of mesenchymal stem cell (MSC) technologies and is focused on developing and marketing products to treat medical conditions in the inflammatory, orthopedic, and cardiovascular areas.

Focus: OSIR’s principal product(s) include Prochymal, for the treatment of steroid refractory Graft versus Host Disease (GvHD), acute GvHD, Crohn’s disease, and acute radiation syndrome; treatment of Type I diabetes mellitus, acute myocardial infarction, chronic obstructive pulmonary disease and Chondrogen, a treatment of osteoarthritis and the reduction of pain in the knee.

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Unilife Medical Poised for NASDAQ: UNIS Trading Debut

January 12th, 2010 Mike Havrilla No comments

During the second week of January, Unilife Medical Solutions (ASX: UNI.AX) (OTC: UNIFF.PK) shareholders overwhelmingly voted in favor of the Company’s U.S. relocation. Unilife is now in the final stages of preparation for a NASDAQ: UNIS stock market trading debut, which is expected to occur by the end of February in conjunction with the Company’s re-domiciliation to Central Pennsylvania. Unilife is emerging as a leading innovator in the medical device manufacturing space with a focus on safety syringes and business segments that include pre-filled syringes for pharmaceutical companies to deliver injected medications, sharps safety devices for healthcare facilities, and contract manufacturing services.

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