Opexa Therapeutics reported (3/5/10) a net loss of $1.43 M or $0.11 per diluted share for FY09 compared to $11.85 M or $1.12 per diluted share in FY08. FY09 highlights:
- The pivotal point in the year was the completion of the stem cell transaction with Novartis (NVS) Pharmaceuticals for an upfront payment of $3 M and potential technology transfer milestone payments totaling another $1 M (with total potential payments from the deal that could exceed $50 M),
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ASTMD reported the final patient treatment in the ongoing cardiac regeneration US P 2 surgical clinical trial designated IMPACT-DCM. Treated at Emory University Hospital Midtown in Atlanta, GA, this patient received direct injections of ASTMD’s tissue repair cells for the treatment of dilated cardiomyopathy (DCM), a severe form of congestive heart failure in which the heart becomes weakened and enlarged and cannot pump blood efficiently.
- With the treatment of the final patient in this trial, Aastrom is positioned to report 6 month interim data on all enrolled patients in late 2010.
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ASTMD has regained compliance with the $1.00 minimum bid price requirement under the NASDAQ Listing Rule.
- On 2/18/10, ASTMD affected a reverse stock split to increase the per-share trading price of its common stock to meet the NASDAQ requirement,
- The ticker symbol for Aastrom Biosciences will revert from ASTMD to ASTM on 3/18/10.
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Geron’s (GERN) collaboration with Corning launches Synthemax™ surface, a novel synthetic surface supporting the growth and differentiation of stem cells and growing hESCs.
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PSTI (3/2/10) received approval from an independent Data Safety Monitoring Board (DSMB) to advance its placenta-derived cell therapy product, PLX-PAD.
- This Phase I study in the EU is to evaluate the safety of PLX-PAD for 3 dosing levels in 15 patients for the treatment of Critical Limb Ischemia (CLI), the end-stage of peripheral artery disease (PAD).
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The FDA has granted Orphan Drug designation for Advanced Cell Technology‘s (ACTC.OB) MA09-hRPE cells for use in the treatment of Stargardt’s Macular Dystrophy (SMD). As a result, ACTC.OB is eligible to receive a number of benefits, including tax credits, access to grant funding for clinical trials, accelerated FDA approval and allowance for marketing exclusivity after drug approval for a period of as long as 7 years.
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Merck KGaA agreed to buy Millipore (MIL), a supplier of drug-development equipment for biotechnology companies for about $6 B in cash, beating a rival offer from Thermo Fisher Scientific. BTIM’s ACTCellerate™ progenitor cell lines and ESpan™ cell growth media sell through MIL. Merck KGaA will pay $107 a share and is a Germany based company. The offer is 13 % more than Millipore’s closing price on 2/26/10 and 50 % higher. Millipore, based in Billerica, Massachusetts, put itself up for sale after getting an unsolicited takeover bid worth less than $95 a share from Thermo Fisher (Bloomberg).
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